Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2240110..2240624 Replicon chromosome
Accession NZ_CP128388
Organism Staphylococcus aureus strain 21-074

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QTN92_RS10720 Protein ID WP_000581792.1
Coordinates 2240415..2240624 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QTN92_RS10715 Protein ID WP_000138932.1
Coordinates 2240110..2240403 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN92_RS10695 (QTN92_10695) 2235873..2237188 + 1316 Protein_2101 ISL3 family transposase -
QTN92_RS10700 (QTN92_10700) 2237166..2237228 - 63 Protein_2102 hypothetical protein -
QTN92_RS10705 (QTN92_10705) 2237785..2238432 - 648 WP_001187614.1 HD domain-containing protein -
QTN92_RS10710 (QTN92_10710) 2238460..2239944 - 1485 WP_000571550.1 cardiolipin synthase -
QTN92_RS10715 (QTN92_10715) 2240110..2240403 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QTN92_RS10720 (QTN92_10720) 2240415..2240624 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QTN92_RS10725 (QTN92_10725) 2240752..2240889 + 138 WP_000828354.1 Lmo0850 family protein -
QTN92_RS10730 (QTN92_10730) 2241153..2242355 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QTN92_RS10735 (QTN92_10735) 2242673..2243743 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QTN92_RS10740 (QTN92_10740) 2243758..2245113 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T284530 WP_000581792.1 NZ_CP128388:2240415-2240624 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT284530 WP_000138932.1 NZ_CP128388:2240110-2240403 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References