Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2420812..2421588 Replicon chromosome
Accession NZ_CP128387
Organism Staphylococcus aureus strain 22-042

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QTN90_RS11780 Protein ID WP_000031108.1
Coordinates 2421436..2421588 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QTN90_RS11775 Protein ID WP_001251224.1
Coordinates 2420812..2421411 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN90_RS11755 (QTN90_11755) 2416728..2418185 + 1458 WP_000649908.1 ABC transporter permease subunit -
QTN90_RS11760 (QTN90_11760) 2418178..2418900 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
QTN90_RS11765 (QTN90_11765) 2419051..2420178 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
QTN90_RS11770 (QTN90_11770) 2420183..2420653 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QTN90_RS11775 (QTN90_11775) 2420812..2421411 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QTN90_RS11780 (QTN90_11780) 2421436..2421588 + 153 WP_000031108.1 SAS053 family protein Toxin
QTN90_RS11785 (QTN90_11785) 2422131..2422526 + 396 WP_000901018.1 hypothetical protein -
QTN90_RS11790 (QTN90_11790) 2422722..2424107 + 1386 WP_000116238.1 class II fumarate hydratase -
QTN90_RS11795 (QTN90_11795) 2424562..2425383 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T284521 WP_000031108.1 NZ_CP128387:2421436-2421588 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT284521 WP_001251224.1 NZ_CP128387:2420812-2421411 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References