Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2259822..2260351 Replicon chromosome
Accession NZ_CP128387
Organism Staphylococcus aureus strain 22-042

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QTN90_RS10865 Protein ID WP_000621175.1
Coordinates 2259989..2260351 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QTN90_RS10860 Protein ID WP_000948331.1
Coordinates 2259822..2259992 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN90_RS10830 (QTN90_10830) 2254858..2255418 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
QTN90_RS10835 (QTN90_10835) 2255627..2256106 + 480 WP_001287081.1 hypothetical protein -
QTN90_RS10840 (QTN90_10840) 2256099..2257676 + 1578 WP_001294650.1 PH domain-containing protein -
QTN90_RS10845 (QTN90_10845) 2257669..2258160 + 492 WP_001286980.1 PH domain-containing protein -
QTN90_RS10850 (QTN90_10850) 2258164..2258523 + 360 WP_000581197.1 holo-ACP synthase -
QTN90_RS10855 (QTN90_10855) 2258589..2259737 + 1149 WP_001281139.1 alanine racemase -
QTN90_RS10860 (QTN90_10860) 2259822..2259992 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QTN90_RS10865 (QTN90_10865) 2259989..2260351 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QTN90_RS10870 (QTN90_10870) 2260701..2261702 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QTN90_RS10875 (QTN90_10875) 2261821..2262147 + 327 WP_001052491.1 anti-sigma factor antagonist -
QTN90_RS10880 (QTN90_10880) 2262149..2262628 + 480 WP_001190825.1 anti-sigma B factor RsbW -
QTN90_RS10885 (QTN90_10885) 2262603..2263373 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T284520 WP_000621175.1 NZ_CP128387:2259989-2260351 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT284520 WP_000948331.1 NZ_CP128387:2259822-2259992 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References