Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2240100..2240614 Replicon chromosome
Accession NZ_CP128387
Organism Staphylococcus aureus strain 22-042

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QTN90_RS10775 Protein ID WP_000581792.1
Coordinates 2240405..2240614 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QTN90_RS10770 Protein ID WP_000138932.1
Coordinates 2240100..2240393 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN90_RS10750 (QTN90_10750) 2235863..2237178 + 1316 Protein_2112 ISL3 family transposase -
QTN90_RS10755 (QTN90_10755) 2237156..2237218 - 63 Protein_2113 hypothetical protein -
QTN90_RS10760 (QTN90_10760) 2237775..2238422 - 648 WP_001187614.1 HD domain-containing protein -
QTN90_RS10765 (QTN90_10765) 2238450..2239934 - 1485 WP_000571550.1 cardiolipin synthase -
QTN90_RS10770 (QTN90_10770) 2240100..2240393 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QTN90_RS10775 (QTN90_10775) 2240405..2240614 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QTN90_RS10780 (QTN90_10780) 2240742..2240879 + 138 WP_000828354.1 Lmo0850 family protein -
QTN90_RS10785 (QTN90_10785) 2241143..2242345 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QTN90_RS10790 (QTN90_10790) 2242663..2243733 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QTN90_RS10795 (QTN90_10795) 2243748..2245103 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T284519 WP_000581792.1 NZ_CP128387:2240405-2240614 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT284519 WP_000138932.1 NZ_CP128387:2240100-2240393 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References