Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pIncI1-ST12
Accession NZ_CP128262
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QR684_RS23085 Protein ID WP_244442846.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QR684_RS23080 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS23075 (46) 46..1077 + 1032 WP_000907873.1 plasmid replication initiator RepA -
QR684_RS23080 (1986) 1986..2255 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QR684_RS23085 (2255) 2255..2533 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QR684_RS23090 (2573) 2573..3421 + 849 WP_001057991.1 3'-5' exonuclease -
QR684_RS23095 (3538) 3538..4011 + 474 WP_001334658.1 hypothetical protein -
QR684_RS23100 (4488) 4488..4754 - 267 WP_000955263.1 hypothetical protein -
QR684_RS23105 (4754) 4754..5248 - 495 WP_001459505.1 hypothetical protein -
QR684_RS23110 (5304) 5304..5906 - 603 WP_000517695.1 ProQ/FINO family protein -
QR684_RS23115 (6260) 6260..7144 + 885 Protein_8 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..101492 101492
- flank IS/Tn blaCMY-2 - 7327..10058 2731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T284508 WP_244442846.1 NZ_CP128262:2255-2533 [Salmonella enterica subsp. enterica serovar Heidelberg]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT284508 WP_000079941.1 NZ_CP128262:1986-2255 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References