Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4147415..4147931 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag QR684_RS20175 Protein ID WP_000220577.1
Coordinates 4147415..4147699 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QR684_RS20180 Protein ID WP_000212724.1
Coordinates 4147689..4147931 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS20160 (4142531) 4142531..4144183 + 1653 WP_000155047.1 alpha,alpha-phosphotrehalase -
QR684_RS20165 (4144592) 4144592..4146730 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QR684_RS20170 (4146947) 4146947..4147411 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QR684_RS20175 (4147415) 4147415..4147699 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QR684_RS20180 (4147689) 4147689..4147931 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QR684_RS20185 (4148009) 4148009..4149922 - 1914 WP_001212135.1 BglG family transcription antiterminator -
QR684_RS20190 (4149939) 4149939..4150679 - 741 WP_000779250.1 KDGP aldolase family protein -
QR684_RS20195 (4150676) 4150676..4151794 - 1119 WP_001139173.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QR684_RS20200 (4151778) 4151778..4152911 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T284505 WP_000220577.1 NZ_CP128261:c4147699-4147415 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT284505 WP_000212724.1 NZ_CP128261:c4147931-4147689 [Salmonella enterica subsp. enterica serovar Heidelberg]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References