Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3406970..3407590 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QR684_RS16645 Protein ID WP_001280991.1
Coordinates 3407372..3407590 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QR684_RS16640 Protein ID WP_000344807.1
Coordinates 3406970..3407344 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS16630 (3402109) 3402109..3403302 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QR684_RS16635 (3403325) 3403325..3406474 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QR684_RS16640 (3406970) 3406970..3407344 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QR684_RS16645 (3407372) 3407372..3407590 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QR684_RS16650 (3407769) 3407769..3408320 + 552 WP_001278792.1 maltose O-acetyltransferase -
QR684_RS16655 (3408437) 3408437..3408907 + 471 WP_000136181.1 YlaC family protein -
QR684_RS16660 (3408963) 3408963..3409103 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QR684_RS16665 (3409109) 3409109..3409369 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QR684_RS16670 (3409594) 3409594..3411144 + 1551 WP_000213139.1 EAL domain-containing protein -
QR684_RS16680 (3411375) 3411375..3411764 + 390 WP_000961285.1 MGMT family protein -
QR684_RS16685 (3411797) 3411797..3412366 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T284501 WP_001280991.1 NZ_CP128261:3407372-3407590 [Salmonella enterica subsp. enterica serovar Heidelberg]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT284501 WP_000344807.1 NZ_CP128261:3406970-3407344 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References