284500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2351968..2352490 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name stbE Uniprot ID A0A5V5H0Y9
Locus tag QR684_RS11320 Protein ID WP_000221348.1
Coordinates 2352206..2352490 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag QR684_RS11315 Protein ID WP_000885424.1
Coordinates 2351968..2352216 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS11290 (2347758) 2347758..2348666 - 909 WP_001176641.1 LysR family transcriptional regulator -
QR684_RS11295 (2349477) 2349477..2350245 + 769 Protein_2207 helix-turn-helix domain-containing protein -
QR684_RS11300 (2350301) 2350301..2351208 - 908 Protein_2208 hypothetical protein -
QR684_RS11305 (2351291) 2351291..2351611 - 321 WP_001531540.1 DUF1493 family protein -
QR684_RS11310 (2351601) 2351601..2351816 - 216 WP_000206207.1 hypothetical protein -
QR684_RS11315 (2351968) 2351968..2352216 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QR684_RS11320 (2352206) 2352206..2352490 + 285 WP_000221348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QR684_RS11325 (2352661) 2352661..2353050 + 390 WP_001531585.1 RidA family protein -
QR684_RS11330 (2353108) 2353108..2354181 - 1074 WP_000954686.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
QR684_RS11335 (2354373) 2354373..2354861 - 489 WP_001293629.1 MarR family winged helix-turn-helix transcriptional regulator -
QR684_RS11340 (2354906) 2354906..2356414 + 1509 WP_000214838.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2348822..2359271 10449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.88 Da        Isoelectric Point: 10.6500

>T284500 WP_000221348.1 NZ_CP128261:2352206-2352490 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYKLAFNESALKEWKKMGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT284500 WP_000885424.1 NZ_CP128261:2351968-2352216 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V5H0Y9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References