Detailed information of TA system TA028450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 299741..300402
• Replicon: chromosome
• Accession: NC_019382
• Organism: Bordetella bronchiseptica 253

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: BN112_RS01520
• Protein ID: WP_003817075.1
• Coordinates: 299741..300166 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BN112_RS01525
• Protein ID: WP_003812071.1
• Coordinates: 300163..300402 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN112_RS01500	295565..296542	+	978	WP_015041576.1	tripartite tricarboxylate transporter substrate binding protein	-
BN112_RS01505	296562..297074	-	513	WP_015063701.1	hypothetical protein	-
BN112_RS01510	297564..299069	+	1506	WP_015063702.1	tripartite tricarboxylate transporter permease	-
BN112_RS01515	299167..299631	-	465	WP_003812075.1	MarR family transcriptional regulator	-
BN112_RS01520	299741..300166	-	426	WP_003817075.1	PIN domain-containing protein	Toxin
BN112_RS01525	300163..300402	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
BN112_RS01530	300476..301318	-	843	WP_015063703.1	AraC family transcriptional regulator	-
BN112_RS01535	301462..302007	+	546	WP_015063704.1	peroxidase-related enzyme	-
BN112_RS01540	302066..302578	+	513	WP_015063705.1	redoxin domain-containing protein	-
BN112_RS01545	302660..302893	+	234	WP_033450420.1	DUF2945 domain-containing protein	-
BN112_RS01550	302890..303450	+	561	WP_015063706.1	DUF488 domain-containing protein	-
BN112_RS01555	303528..304574	+	1047	WP_015063707.1	Dyp-type peroxidase	-
BN112_RS01560	304571..305374	+	804	WP_015063708.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T28450 WP_003817075.1 NC_019382:c300166-299741 [Bordetella bronchiseptica 253]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T28450 NC_019382:c300166-299741 [Bordetella bronchiseptica 253]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT28450 WP_003812071.1 NC_019382:c300402-300163 [Bordetella bronchiseptica 253]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT28450 NC_019382:c300402-300163 [Bordetella bronchiseptica 253]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6