Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 828707..829367 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name cptA Uniprot ID A0A5V1QI13
Locus tag QR684_RS04005 Protein ID WP_000244754.1
Coordinates 828954..829367 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag QR684_RS04000 Protein ID WP_000351186.1
Coordinates 828707..828973 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS03980 (824635) 824635..826068 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
QR684_RS03985 (826227) 826227..826538 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
QR684_RS03990 (826702) 826702..827361 + 660 WP_000250288.1 hemolysin III family protein -
QR684_RS03995 (827477) 827477..828457 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
QR684_RS04000 (828707) 828707..828973 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
QR684_RS04005 (828954) 828954..829367 + 414 WP_000244754.1 protein YgfX Toxin
QR684_RS04010 (829420) 829420..829941 - 522 WP_001055885.1 flavodoxin FldB -
QR684_RS04015 (830054) 830054..830950 + 897 WP_000434301.1 site-specific tyrosine recombinase XerD -
QR684_RS04020 (830974) 830974..831687 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QR684_RS04025 (831693) 831693..833426 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T284494 WP_000244754.1 NZ_CP128261:828954-829367 [Salmonella enterica subsp. enterica serovar Heidelberg]
VVLWQSDLRVSWRAQWISLLIHGLIAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT284494 WP_000351186.1 NZ_CP128261:828707-828973 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V1QI13

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References