Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 2068437..2069053 | Replicon | chromosome |
Accession | NZ_CP128260 | ||
Organism | Pseudomonas fluorescens strain PH.SM |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | QR290_RS09425 | Protein ID | WP_085611511.1 |
Coordinates | 2068437..2068649 (+) | Length | 71 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | QR290_RS09430 | Protein ID | WP_085699412.1 |
Coordinates | 2068649..2069053 (+) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QR290_RS09390 (QR290_09390) | 2063555..2064091 | + | 537 | WP_011333088.1 | DsbE family thiol:disulfide interchange protein | - |
QR290_RS09395 (QR290_09395) | 2064088..2064558 | + | 471 | WP_011333089.1 | cytochrome c-type biogenesis protein CcmH | - |
QR290_RS09400 (QR290_09400) | 2064555..2065757 | + | 1203 | WP_289204772.1 | c-type cytochrome biogenesis protein CcmI | - |
QR290_RS09405 (QR290_09405) | 2065783..2066190 | + | 408 | WP_115077021.1 | hypothetical protein | - |
QR290_RS09410 (QR290_09410) | 2066243..2066746 | - | 504 | WP_205350854.1 | PIN domain-containing protein | - |
QR290_RS09415 (QR290_09415) | 2066828..2067295 | - | 468 | WP_007959254.1 | helix-turn-helix domain-containing protein | - |
QR290_RS09420 (QR290_09420) | 2067379..2068266 | - | 888 | WP_289204773.1 | LysR family transcriptional regulator | - |
QR290_RS09425 (QR290_09425) | 2068437..2068649 | + | 213 | WP_085611511.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
QR290_RS09430 (QR290_09430) | 2068649..2069053 | + | 405 | WP_085699412.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
QR290_RS09435 (QR290_09435) | 2069100..2070287 | - | 1188 | WP_289204774.1 | MFS transporter | - |
QR290_RS09440 (QR290_09440) | 2070529..2071149 | + | 621 | WP_115077026.1 | DUF5666 domain-containing protein | - |
QR290_RS09445 (QR290_09445) | 2071205..2072203 | - | 999 | WP_115077027.1 | sulfate ABC transporter substrate-binding protein | - |
QR290_RS09450 (QR290_09450) | 2072311..2073135 | - | 825 | WP_115077028.1 | ion transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 71 a.a. Molecular weight: 8018.18 Da Isoelectric Point: 10.4352
>T284487 WP_085611511.1 NZ_CP128260:2068437-2068649 [Pseudomonas fluorescens]
VQSRLLIKELEEAGWTLDRITGSHHIFTHRYNPYTIPVPHPKKDLPVGTVKSIRRRAGLYNPPASYRGDP
VQSRLLIKELEEAGWTLDRITGSHHIFTHRYNPYTIPVPHPKKDLPVGTVKSIRRRAGLYNPPASYRGDP
Download Length: 213 bp
Antitoxin
Download Length: 135 a.a. Molecular weight: 14806.76 Da Isoelectric Point: 4.3841
>AT284487 WP_085699412.1 NZ_CP128260:2068649-2069053 [Pseudomonas fluorescens]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIAADGDSIPMPTSAAAHRNNPEFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIAADGDSIPMPTSAAAHRNNPEFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH
Download Length: 405 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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