284486

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2066243..2067295 Replicon chromosome
Accession NZ_CP128260
Organism Pseudomonas fluorescens strain PH.SM

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag QR290_RS09410 Protein ID WP_205350854.1
Coordinates 2066243..2066746 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID J2X4E7
Locus tag QR290_RS09415 Protein ID WP_007959254.1
Coordinates 2066828..2067295 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR290_RS09385 (QR290_09385) 2061570..2063558 + 1989 WP_289204771.1 heme lyase CcmF/NrfE family subunit -
QR290_RS09390 (QR290_09390) 2063555..2064091 + 537 WP_011333088.1 DsbE family thiol:disulfide interchange protein -
QR290_RS09395 (QR290_09395) 2064088..2064558 + 471 WP_011333089.1 cytochrome c-type biogenesis protein CcmH -
QR290_RS09400 (QR290_09400) 2064555..2065757 + 1203 WP_289204772.1 c-type cytochrome biogenesis protein CcmI -
QR290_RS09405 (QR290_09405) 2065783..2066190 + 408 WP_115077021.1 hypothetical protein -
QR290_RS09410 (QR290_09410) 2066243..2066746 - 504 WP_205350854.1 PIN domain-containing protein Toxin
QR290_RS09415 (QR290_09415) 2066828..2067295 - 468 WP_007959254.1 helix-turn-helix domain-containing protein Antitoxin
QR290_RS09420 (QR290_09420) 2067379..2068266 - 888 WP_289204773.1 LysR family transcriptional regulator -
QR290_RS09425 (QR290_09425) 2068437..2068649 + 213 WP_085611511.1 type II toxin-antitoxin system HicA family toxin -
QR290_RS09430 (QR290_09430) 2068649..2069053 + 405 WP_085699412.1 type II toxin-antitoxin system HicB family antitoxin -
QR290_RS09435 (QR290_09435) 2069100..2070287 - 1188 WP_289204774.1 MFS transporter -
QR290_RS09440 (QR290_09440) 2070529..2071149 + 621 WP_115077026.1 DUF5666 domain-containing protein -
QR290_RS09445 (QR290_09445) 2071205..2072203 - 999 WP_115077027.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-91)

Antitoxin

SinI-like, DNA-binding domain

(84-130)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18826.69 Da        Isoelectric Point: 5.5879

>T284486 WP_205350854.1 NZ_CP128260:c2066746-2066243 [Pseudomonas fluorescens]
MWLALSGRFRARWTQEIHCEWKRNLLKNRPDLTMEQLDRTSALMDQAIPDACFHDYEDLIAGLSLPDCDDRHVLAAAIRC
GASVIVTFNQKDFPCKALEPFGIEAQHPDEFVDNLLGLDPAAVVAAAQKQRRQLKMPAMDVEPFLDLLQRQGLVKSVQAL
SGYHAIL

Download         Length: 504 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17272.70 Da        Isoelectric Point: 6.4962

>AT284486 WP_007959254.1 NZ_CP128260:c2067295-2066828 [Pseudomonas fluorescens]
MSTVIHPSISLPVEREVKAAIEGQRALAAYLATHFETQHIQIFDEQNEAHRVELPTSALRLLIDILAELAAGNAVQVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFADLMDYKTRRTTASEQAMALLAEQAQALRTGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J2X4E7

References