Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 519184..519827 Replicon chromosome
Accession NZ_CP128260
Organism Pseudomonas fluorescens strain PH.SM

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QR290_RS02280 Protein ID WP_289204245.1
Coordinates 519184..519366 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QR290_RS02285 Protein ID WP_289204246.1
Coordinates 519426..519827 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR290_RS02265 (QR290_02265) 515273..516199 + 927 WP_007952730.1 serine acetyltransferase -
QR290_RS02270 (QR290_02270) 516671..518632 + 1962 WP_289205264.1 choline transporter BetT -
QR290_RS02275 (QR290_02275) 518657..518917 - 261 WP_007952727.1 hypothetical protein -
QR290_RS02280 (QR290_02280) 519184..519366 + 183 WP_289204245.1 type II toxin-antitoxin system HicA family toxin Toxin
QR290_RS02285 (QR290_02285) 519426..519827 + 402 WP_289204246.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QR290_RS02290 (QR290_02290) 519850..520887 - 1038 WP_115076170.1 LacI family DNA-binding transcriptional regulator -
QR290_RS02295 (QR290_02295) 521094..523319 + 2226 WP_289204247.1 TonB-dependent receptor -
QR290_RS02300 (QR290_02300) 523321..524640 + 1320 WP_115076172.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6778.92 Da        Isoelectric Point: 10.7495

>T284483 WP_289204245.1 NZ_CP128260:519184-519366 [Pseudomonas fluorescens]
MRSREMIRMIEEGGWYLVAVKGSHHQYKHPGKPGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14568.38 Da        Isoelectric Point: 4.3652

>AT284483 WP_289204246.1 NZ_CP128260:519426-519827 [Pseudomonas fluorescens]
MKFPVVLHKDADSDYGVIIPDVPGCFSAGTTVAEAFDNTLEALALHYEGLVADGAPLPRIQDIDAHLENPDYAGGIWGVV
EFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSTRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References