Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4638677..4639174 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QRX22_RS22715 Protein ID WP_001173343.1
Coordinates 4638677..4638850 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QRX22_RS22720 Protein ID WP_001312331.1
Coordinates 4638878..4639174 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS22705 (4635347) 4635347..4636804 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QRX22_RS22710 (4637041) 4637041..4638558 + 1518 WP_000003806.1 lysine--tRNA ligase -
QRX22_RS22715 (4638677) 4638677..4638850 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QRX22_RS22720 (4638878) 4638878..4639174 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRX22_RS22725 (4639403) 4639403..4639675 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRX22_RS22730 (4639687) 4639687..4639917 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
QRX22_RS22735 (4640098) 4640098..4641729 + 1632 WP_001216482.1 sensor histidine kinase -
QRX22_RS22740 (4641726) 4641726..4642445 + 720 WP_001540474.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284478 WP_001173343.1 NZ_CP128255:c4638850-4638677 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT284478 WP_001312331.1 NZ_CP128255:c4639174-4638878 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References