Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 994359..995013 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QRX22_RS04910 Protein ID WP_000244781.1
Coordinates 994606..995013 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRX22_RS04905 Protein ID WP_000354046.1
Coordinates 994359..994625 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS04885 (990447) 990447..991880 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QRX22_RS04890 (991925) 991925..992236 + 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
QRX22_RS04895 (992400) 992400..993059 + 660 WP_000250274.1 hemolysin III family protein -
QRX22_RS04900 (993136) 993136..994116 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
QRX22_RS04905 (994359) 994359..994625 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRX22_RS04910 (994606) 994606..995013 + 408 WP_000244781.1 protein YgfX Toxin
QRX22_RS04915 (995053) 995053..995574 - 522 WP_001055874.1 flavodoxin FldB -
QRX22_RS04920 (995686) 995686..996582 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QRX22_RS04925 (996607) 996607..997317 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRX22_RS04930 (997323) 997323..999056 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T284462 WP_000244781.1 NZ_CP128255:994606-995013 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284462 WP_000354046.1 NZ_CP128255:994359-994625 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References