Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 765039..765867 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag QRX22_RS03770 Protein ID WP_000854814.1
Coordinates 765493..765867 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L5H9Y2
Locus tag QRX22_RS03765 Protein ID WP_033559079.1
Coordinates 765039..765404 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS03735 (761925) 761925..762380 + 456 WP_000581502.1 IrmA family protein -
QRX22_RS03740 (762523) 762523..762612 + 90 WP_112031555.1 DUF905 family protein -
QRX22_RS03745 (762791) 762791..763612 + 822 WP_289201249.1 DUF932 domain-containing protein -
QRX22_RS03750 (763704) 763704..764189 + 486 WP_000214310.1 antirestriction protein -
QRX22_RS03755 (764205) 764205..764681 + 477 WP_289201250.1 RadC family protein -
QRX22_RS03760 (764744) 764744..764965 + 222 WP_289201251.1 DUF987 domain-containing protein -
QRX22_RS03765 (765039) 765039..765404 + 366 WP_033559079.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QRX22_RS03770 (765493) 765493..765867 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QRX22_RS03775 (765864) 765864..766355 + 492 WP_128972961.1 DUF5983 family protein -
QRX22_RS03780 (766367) 766367..766564 + 198 WP_033559078.1 DUF957 domain-containing protein -
QRX22_RS03785 (766649) 766649..767494 + 846 WP_112031439.1 DUF4942 domain-containing protein -
QRX22_RS03795 (767793) 767793..768299 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
QRX22_RS03800 (768377) 768377..770218 - 1842 WP_000437380.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T284461 WP_000854814.1 NZ_CP128255:765493-765867 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13567.47 Da        Isoelectric Point: 7.3222

>AT284461 WP_033559079.1 NZ_CP128255:765039-765404 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A3L5H9Y2

References