Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09812-MazE
Location 1344967..1345559 Replicon chromosome
Accession NZ_CP128233
Organism Paralcaligenes sp. CC-YST667

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N7E01_RS07230 Protein ID WP_289175223.1
Coordinates 1345212..1345559 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag N7E01_RS07225 Protein ID WP_289175220.1
Coordinates 1344967..1345212 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E01_RS07195 (N7E01_07195) 1340598..1340774 - 177 WP_289175208.1 hypothetical protein -
N7E01_RS07200 (N7E01_07200) 1340849..1341172 + 324 WP_289175210.1 hypothetical protein -
N7E01_RS07205 (N7E01_07205) 1341066..1342339 + 1274 Protein_1414 hypothetical protein -
N7E01_RS07210 (N7E01_07210) 1342336..1342596 - 261 WP_289175211.1 hypothetical protein -
N7E01_RS07215 (N7E01_07215) 1342595..1343011 + 417 WP_289175214.1 hypothetical protein -
N7E01_RS07220 (N7E01_07220) 1343008..1344858 + 1851 WP_289175217.1 nucleoside-diphosphate sugar epimerase/dehydratase -
N7E01_RS07225 (N7E01_07225) 1344967..1345212 + 246 WP_289175220.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N7E01_RS07230 (N7E01_07230) 1345212..1345559 + 348 WP_289175223.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N7E01_RS07235 (N7E01_07235) 1345655..1347097 - 1443 WP_289175225.1 TolC family outer membrane protein -
N7E01_RS07240 (N7E01_07240) 1347158..1348501 - 1344 WP_289175227.1 HlyD family type I secretion periplasmic adaptor subunit -
N7E01_RS07245 (N7E01_07245) 1348503..1349879 - 1377 WP_289175228.1 type I secretion system permease/ATPase -
N7E01_RS07250 (N7E01_07250) 1349885..1350244 - 360 WP_289175230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12372.20 Da        Isoelectric Point: 6.8593

>T284449 WP_289175223.1 NZ_CP128233:1345212-1345559 [Paralcaligenes sp. CC-YST667]
MAYVPNRGDIVHLEFDPSSGNEIKGPHFGLVLSAKVFNQQGLAMICPISQGAAAAARTYGTVVTLMGSGTDTQGAVHCHQ
LKSLDWQARKVRLKETAPQPIVDEVLARVEAILFD

Download         Length: 348 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8843.24 Da        Isoelectric Point: 5.0351

>AT284449 WP_289175220.1 NZ_CP128233:1344967-1345212 [Paralcaligenes sp. CC-YST667]
MLQTLRKAGGSLVMTVPKAFIDQNGLGEGSQVELKLSGTKMTIEAPKRPRYKLTDLMAEMGQGLPHIEGWDDMPSVGLEN
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References