Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4154660..4155474 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QSI84_RS20285 Protein ID WP_001054376.1
Coordinates 4155217..4155474 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QSI84_RS20280 Protein ID WP_001309181.1
Coordinates 4154660..4155205 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS20250 (4150351) 4150351..4151664 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
QSI84_RS20255 (4151676) 4151676..4151954 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QSI84_RS20260 (4151951) 4151951..4153072 - 1122 WP_000010829.1 M42 family metallopeptidase -
QSI84_RS20265 (4153317) 4153317..4153433 - 117 Protein_3940 VOC family protein -
QSI84_RS20270 (4153471) 4153471..4153689 - 219 Protein_3941 hypothetical protein -
QSI84_RS20275 (4153858) 4153858..4154604 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QSI84_RS20280 (4154660) 4154660..4155205 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
QSI84_RS20285 (4155217) 4155217..4155474 - 258 WP_001054376.1 YjhX family toxin Toxin
QSI84_RS20290 (4155965) 4155965..4156096 - 132 WP_001309182.1 hypothetical protein -
QSI84_RS20295 (4156212) 4156212..4157452 + 1241 Protein_3946 helicase YjhR -
QSI84_RS20300 (4157720) 4157720..4157925 - 206 Protein_3947 HNH endonuclease -
QSI84_RS20305 (4158035) 4158035..4159015 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QSI84_RS20310 (4159080) 4159080..4160186 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4154660..4170118 15458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T284433 WP_001054376.1 NZ_CP128218:c4155474-4155217 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT284433 WP_001309181.1 NZ_CP128218:c4155205-4154660 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References