284432

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4069868..4070463 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag QSI84_RS19855 Protein ID WP_000239577.1
Coordinates 4070113..4070463 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QSI84_RS19850 Protein ID WP_001223208.1
Coordinates 4069868..4070119 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS19840 (4065533) 4065533..4069312 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
QSI84_RS19845 (4069315) 4069315..4069656 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QSI84_RS19850 (4069868) 4069868..4070119 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QSI84_RS19855 (4070113) 4070113..4070463 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
QSI84_RS19860 (4070543) 4070543..4071073 - 531 WP_038432732.1 inorganic diphosphatase -
QSI84_RS19865 (4071383) 4071383..4072339 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QSI84_RS19870 (4072479) 4072479..4073981 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
QSI84_RS19875 (4073995) 4073995..4075017 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T284432 WP_000239577.1 NZ_CP128218:4070113-4070463 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT284432 WP_001223208.1 NZ_CP128218:4069868-4070119 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References