Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3974005..3974502 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QSI84_RS19360 Protein ID WP_001173343.1
Coordinates 3974329..3974502 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QSI84_RS19355 Protein ID WP_000398619.1
Coordinates 3974005..3974301 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS19335 (3970736) 3970736..3971455 - 720 WP_000611288.1 two-component system response regulator DcuR -
QSI84_RS19340 (3971452) 3971452..3973083 - 1632 WP_001216477.1 sensor histidine kinase -
QSI84_RS19345 (3973264) 3973264..3973494 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QSI84_RS19350 (3973506) 3973506..3973778 + 273 WP_000405651.1 GNAT family N-acetyltransferase -
QSI84_RS19355 (3974005) 3974005..3974301 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QSI84_RS19360 (3974329) 3974329..3974502 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QSI84_RS19365 (3974621) 3974621..3976138 - 1518 WP_001295074.1 lysine--tRNA ligase -
QSI84_RS19370 (3976375) 3976375..3977832 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284431 WP_001173343.1 NZ_CP128218:3974329-3974502 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284431 WP_000398619.1 NZ_CP128218:3974005-3974301 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References