Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2659912..2660566 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QSI84_RS13065 Protein ID WP_000244777.1
Coordinates 2659912..2660319 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QSI84_RS13070 Protein ID WP_000354046.1
Coordinates 2660300..2660566 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS13045 (2655869) 2655869..2657602 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
QSI84_RS13050 (2657608) 2657608..2658318 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QSI84_RS13055 (2658343) 2658343..2659239 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QSI84_RS13060 (2659351) 2659351..2659872 + 522 WP_001055874.1 flavodoxin FldB -
QSI84_RS13065 (2659912) 2659912..2660319 - 408 WP_000244777.1 protein YgfX Toxin
QSI84_RS13070 (2660300) 2660300..2660566 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QSI84_RS13075 (2660809) 2660809..2661789 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QSI84_RS13080 (2661985) 2661985..2662644 - 660 WP_000250274.1 hemolysin III family protein -
QSI84_RS13085 (2662808) 2662808..2663119 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QSI84_RS13090 (2663164) 2663164..2664597 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QSI84_RS13095 (2664654) 2664654..2665397 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T284427 WP_000244777.1 NZ_CP128218:c2660319-2659912 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284427 WP_000354046.1 NZ_CP128218:c2660566-2660300 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References