284425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2396611..2397278 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag QSI84_RS11840 Protein ID WP_001094400.1
Coordinates 2396949..2397278 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag QSI84_RS11835 Protein ID WP_000072690.1
Coordinates 2396611..2396928 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS11805 (2391663) 2391663..2392672 - 1010 Protein_2306 arsenic transporter -
QSI84_RS11810 (2392814) 2392814..2394517 + 1704 WP_000896263.1 protein YfjW -
QSI84_RS11815 (2395128) 2395128..2395312 + 185 Protein_2308 DUF905 family protein -
QSI84_RS11820 (2395415) 2395415..2395873 + 459 WP_000211841.1 antirestriction protein -
QSI84_RS11825 (2395882) 2395882..2396364 + 483 WP_001407480.1 RadC family protein -
QSI84_RS11830 (2396373) 2396373..2396573 + 201 WP_001395452.1 DUF987 domain-containing protein -
QSI84_RS11835 (2396611) 2396611..2396928 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QSI84_RS11840 (2396949) 2396949..2397278 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
QSI84_RS11845 (2397642) 2397642..2402222 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T284425 WP_001094400.1 NZ_CP128218:2396949-2397278 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT284425 WP_000072690.1 NZ_CP128218:2396611-2396928 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References