Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2385414..2386851 | Replicon | chromosome |
| Accession | NZ_CP128218 | ||
| Organism | Escherichia coli strain TG1 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | QSI84_RS11760 | Protein ID | WP_000155570.1 |
| Coordinates | 2385414..2386487 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | QSI84_RS11765 | Protein ID | WP_000461704.1 |
| Coordinates | 2386480..2386851 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QSI84_RS11745 (2380847) | 2380847..2383036 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| QSI84_RS11750 (2383033) | 2383033..2384649 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| QSI84_RS11755 (2385009) | 2385009..2385272 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| QSI84_RS11760 (2385414) | 2385414..2386487 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| QSI84_RS11765 (2386480) | 2386480..2386851 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| QSI84_RS11770 (2387206) | 2387206..2388069 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| QSI84_RS11775 (2388161) | 2388161..2388982 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| QSI84_RS11780 (2389199) | 2389199..2389900 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| QSI84_RS11785 (2389941) | 2389941..2390177 | + | 237 | WP_001144029.1 | protein YpjK | - |
| QSI84_RS11790 (2390177) | 2390177..2390620 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| QSI84_RS11795 (2390644) | 2390644..2391111 | + | 468 | WP_000702495.1 | protein YfjT | - |
| QSI84_RS11800 (2391498) | 2391498..2391650 | - | 153 | Protein_2305 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T284424 WP_000155570.1 NZ_CP128218:2385414-2386487 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT284424 WP_000461704.1 NZ_CP128218:2386480-2386851 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|