Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2129742..2130228 Replicon
Accession NC_019042
Organism Streptococcus dysgalactiae subsp. equisimilis AC-2713

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag SDSE_RS20965 Protein ID WP_014407961.1
Coordinates 2129742..2130011 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag SDSE_RS20970 Protein ID WP_014407962.1
Coordinates 2130001..2130228 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDSE_RS20950 2124874..2127147 - 2274 WP_015058145.1 YhgE/Pip domain-containing protein -
SDSE_RS20955 2127282..2127815 + 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
SDSE_RS20960 2127812..2129314 - 1503 WP_015058146.1 IS1182 family transposase -
SDSE_RS20965 2129742..2130011 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SDSE_RS20970 2130001..2130228 - 228 WP_014407962.1 hypothetical protein Antitoxin
SDSE_RS21625 2130381..2130753 - 373 Protein_1999 ArpU family transcriptional regulator -
SDSE_RS20975 2130728..2131090 - 363 WP_015058149.1 DUF1492 domain-containing protein -
SDSE_RS20980 2131369..2131614 - 246 WP_011285304.1 hypothetical protein -
SDSE_RS20985 2131589..2131864 - 276 WP_014407964.1 hypothetical protein -
SDSE_RS20990 2131854..2132192 - 339 WP_030126557.1 replication protein -
SDSE_RS20995 2132234..2132500 - 267 WP_011285307.1 hypothetical protein -
SDSE_RS21000 2132497..2133285 - 789 WP_015058150.1 hypothetical protein -
SDSE_RS21825 2133376..2133534 - 159 WP_015058151.1 hypothetical protein -
SDSE_RS21010 2133548..2133793 - 246 WP_015058152.1 hypothetical protein -
SDSE_RS21015 2133789..2134115 - 327 Protein_2008 hypothetical protein -
SDSE_RS21830 2134117..2134290 - 174 WP_015058154.1 hypothetical protein -
SDSE_RS21630 2134296..2134469 - 174 WP_015058155.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2107637..2159253 51616
- flank IS/Tn - - 2127812..2129314 1502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T28442 WP_014407961.1 NC_019042:c2130011-2129742 [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T28442 NC_019042:c2130011-2129742 [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT28442 WP_014407962.1 NC_019042:c2130228-2130001 [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT28442 NC_019042:c2130228-2130001 [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCGCAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References