284415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1131653..1132291 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QSI84_RS05630 Protein ID WP_000813794.1
Coordinates 1131653..1131829 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QSI84_RS05635 Protein ID WP_001270286.1
Coordinates 1131875..1132291 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS05610 (1127272) 1127272..1128447 - 1176 WP_001236265.1 BenE family transporter YdcO -
QSI84_RS05615 (1128539) 1128539..1129075 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QSI84_RS05620 (1129148) 1129148..1131109 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QSI84_RS05625 (1131201) 1131201..1131431 - 231 WP_000494244.1 YncJ family protein -
QSI84_RS05630 (1131653) 1131653..1131829 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QSI84_RS05635 (1131875) 1131875..1132291 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QSI84_RS05640 (1132370) 1132370..1133776 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QSI84_RS05645 (1134021) 1134021..1135166 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QSI84_RS05650 (1135184) 1135184..1136197 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QSI84_RS05655 (1136198) 1136198..1137139 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T284415 WP_000813794.1 NZ_CP128218:1131653-1131829 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT284415 WP_001270286.1 NZ_CP128218:1131875-1132291 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References