Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 102698..103316 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag QSI84_RS00520 Protein ID WP_001290581.1
Coordinates 102698..102916 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QSI84_RS00525 Protein ID WP_000344800.1
Coordinates 102942..103316 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS00485 (97987) 97987..98559 + 573 WP_000779842.1 YbaY family lipoprotein -
QSI84_RS00490 (98590) 98590..98901 - 312 WP_000409911.1 MGMT family protein -
QSI84_RS00500 (99280) 99280..99633 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QSI84_RS00505 (99675) 99675..101225 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QSI84_RS00510 (101389) 101389..101859 - 471 WP_000136192.1 YlaC family protein -
QSI84_RS00515 (101975) 101975..102526 - 552 WP_000102564.1 maltose O-acetyltransferase -
QSI84_RS00520 (102698) 102698..102916 - 219 WP_001290581.1 HHA domain-containing protein Toxin
QSI84_RS00525 (102942) 102942..103316 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QSI84_RS00530 (103862) 103862..107011 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QSI84_RS00535 (107034) 107034..108227 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T284411 WP_001290581.1 NZ_CP128218:c102916-102698 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284411 WP_000344800.1 NZ_CP128218:c103316-102942 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References