Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 946359..946983 Replicon chromosome
Accession NC_018939
Organism Helicobacter pylori 26695

Toxin (Protein)


Gene name relE Uniprot ID O25554
Locus tag C694_RS04540 Protein ID WP_000916169.1
Coordinates 946359..946625 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O25555
Locus tag C694_RS04545 Protein ID WP_001134075.1
Coordinates 946606..946983 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C694_RS04510 942361..943128 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
C694_RS04515 943128..944108 - 981 WP_000921458.1 iron ABC transporter permease -
C694_RS04520 944101..944949 - 849 WP_000504124.1 SDR family oxidoreductase -
C694_RS04525 945089..945613 + 525 WP_001135603.1 acyl-CoA thioesterase -
C694_RS04530 945705..945977 - 273 WP_000955518.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family -
C694_RS04535 945991..946278 - 288 WP_001134157.1 type II toxin-antitoxin system antitoxin -
C694_RS04540 946359..946625 - 267 WP_000916169.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C694_RS04545 946606..946983 - 378 WP_001134075.1 hypothetical protein Antitoxin
C694_RS04555 947594..949720 - 2127 WP_000753173.1 Hop family adhesin BabB -
C694_RS08415 950524..950787 - 264 WP_015056067.1 hypothetical protein -
C694_RS04575 950754..951866 - 1113 WP_000109824.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10344.18 Da        Isoelectric Point: 8.0602

>T28441 WP_000916169.1 NC_018939:c946625-946359 [Helicobacter pylori 26695]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDVLLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T28441 NC_018939:c946625-946359 [Helicobacter pylori 26695]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14713.74 Da        Isoelectric Point: 9.0068

>AT28441 WP_001134075.1 NC_018939:c946983-946606 [Helicobacter pylori 26695]
MPNTTAKKDYTKYSKKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIETQQAMRDVGNKETDLIVEDFSSYSNERKRALGVEAQS

Download         Length: 378 bp

>AT28441 NC_018939:c946983-946606 [Helicobacter pylori 26695]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCAAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAATTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGTCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGTAGGTAACAAAGAGACAGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCAATGAAAGAAAAAGGGCTTTAGGTGTTGAAGCTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1Z8M
PDB 4LSY
PDB 4LTT
PDB 4LS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9KIQ1

References