Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1568937..1569544 Replicon chromosome
Accession NZ_CP128214
Organism Agrobacterium fabrum strain ARqua1

Toxin (Protein)


Gene name relE Uniprot ID Q7D0B7
Locus tag QOV31_RS07720 Protein ID WP_010971265.1
Coordinates 1569209..1569544 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A9CJP8
Locus tag QOV31_RS07715 Protein ID WP_010971266.1
Coordinates 1568937..1569212 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOV31_RS07685 (QOV31_001526) 1564093..1564452 - 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin -
QOV31_RS07690 (QOV31_001527) 1564452..1564718 - 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QOV31_RS07695 (QOV31_001528) 1564788..1564988 - 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
QOV31_RS07700 (QOV31_001529) 1565041..1565463 - 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
QOV31_RS07705 (QOV31_001530) 1565460..1568045 - 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
QOV31_RS07710 (QOV31_001531) 1568221..1568829 - 609 WP_010971267.1 class I SAM-dependent methyltransferase -
QOV31_RS07715 (QOV31_001532) 1568937..1569212 + 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QOV31_RS07720 (QOV31_001533) 1569209..1569544 + 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin Toxin
QOV31_RS07725 (QOV31_001534) 1569572..1570396 - 825 WP_010971264.1 class D beta-lactamase -
QOV31_RS07730 (QOV31_001535) 1570508..1570987 - 480 WP_010971263.1 YcgN family cysteine cluster protein -
QOV31_RS07735 (QOV31_001536) 1571244..1573439 + 2196 WP_035256415.1 transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(23-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-67)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12991.86 Da        Isoelectric Point: 10.0059

>T284409 WP_010971265.1 NZ_CP128214:1569209-1569544 [Agrobacterium fabrum]
VTNKKDHGKDAALKRATLPRRSDFTKQFIKDWQRLNNSGRYDMVRLKEIMLLLIANGAPLPTQFRDHELTGDWRDHRECH
VGGDFLLIYTVDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9918.40 Da        Isoelectric Point: 6.3350

>AT284409 WP_010971266.1 NZ_CP128214:1568937-1569212 [Agrobacterium fabrum]
MTANAYVRARIDQTLKDDATAVLDRLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAAGRNRFGTSE
ALFEALDAGKR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B7

Antitoxin

Source ID Structure
AlphaFold DB A9CJP8

References