Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1564093..1564718 Replicon chromosome
Accession NZ_CP128214
Organism Agrobacterium fabrum strain ARqua1

Toxin (Protein)


Gene name mazF Uniprot ID Q7D0B1
Locus tag QOV31_RS07685 Protein ID WP_006311244.1
Coordinates 1564093..1564452 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q7D0B2
Locus tag QOV31_RS07690 Protein ID WP_010971270.1
Coordinates 1564452..1564718 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOV31_RS07665 (QOV31_001522) 1560231..1561949 + 1719 WP_035256424.1 glycoside hydrolase family 32 protein -
QOV31_RS07670 (QOV31_001523) 1562018..1562191 + 174 WP_010971273.1 hypothetical protein -
QOV31_RS07675 (QOV31_001524) 1562270..1563658 - 1389 WP_169539085.1 MFS transporter -
QOV31_RS07680 (QOV31_001525) 1563837..1564085 + 249 WP_006311245.1 hypothetical protein -
QOV31_RS07685 (QOV31_001526) 1564093..1564452 - 360 WP_006311244.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QOV31_RS07690 (QOV31_001527) 1564452..1564718 - 267 WP_010971270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QOV31_RS07695 (QOV31_001528) 1564788..1564988 - 201 WP_006311242.1 heavy-metal-associated domain-containing protein -
QOV31_RS07700 (QOV31_001529) 1565041..1565463 - 423 WP_006311241.1 Cu(I)-responsive transcriptional regulator -
QOV31_RS07705 (QOV31_001530) 1565460..1568045 - 2586 WP_035256421.1 heavy metal translocating P-type ATPase -
QOV31_RS07710 (QOV31_001531) 1568221..1568829 - 609 WP_010971267.1 class I SAM-dependent methyltransferase -
QOV31_RS07715 (QOV31_001532) 1568937..1569212 + 276 WP_010971266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
QOV31_RS07720 (QOV31_001533) 1569209..1569544 + 336 WP_010971265.1 type II toxin-antitoxin system YafQ family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12857.04 Da        Isoelectric Point: 8.2782

>T284408 WP_006311244.1 NZ_CP128214:c1564452-1564093 [Agrobacterium fabrum]
MVRNQIPKRGDVYLVDLNPVVGSEIKDEHRCVVITPREINAVGLCLVVPVTTGGMFTRKAGLAVNISGHKTTGVALCNQV
RSMDIVARVAQKKAKYIETLDDATIDEIAGRVISMIDPA

Download         Length: 360 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9423.02 Da        Isoelectric Point: 5.1106

>AT284408 WP_010971270.1 NZ_CP128214:c1564718-1564452 [Agrobacterium fabrum]
MTVTTKIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRLEKKRFTLAELLDGAEEVAALNARERAWDTA
PPVGKEAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7D0B1

Antitoxin

Source ID Structure
AlphaFold DB Q7D0B2

References