Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 5690..6270 Replicon plasmid p3_KP0714
Accession NZ_CP128194
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag QSG82_RS29225 Protein ID WP_071177730.1
Coordinates 5690..6004 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QSG82_RS29230 Protein ID WP_000093040.1
Coordinates 5992..6270 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS29200 (QSG82_29200) 1634..3598 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
QSG82_RS29205 (QSG82_29205) 3598..4329 + 732 WP_071177728.1 MobC family replication-relaxation protein -
QSG82_RS29210 (QSG82_29210) 4336..4866 + 531 WP_071177729.1 hypothetical protein -
QSG82_RS29215 (QSG82_29215) 4893..5072 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
QSG82_RS29220 (QSG82_29220) 5098..5526 - 429 WP_001140599.1 hypothetical protein -
QSG82_RS29225 (QSG82_29225) 5690..6004 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QSG82_RS29230 (QSG82_29230) 5992..6270 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QSG82_RS29235 (QSG82_29235) 6445..6810 - 366 WP_072354022.1 TonB family protein -
QSG82_RS29240 (QSG82_29240) 6807..7178 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QSG82_RS29245 (QSG82_29245) 7452..7697 - 246 WP_032440458.1 hypothetical protein -
QSG82_RS29250 (QSG82_29250) 8024..9709 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
QSG82_RS29255 (QSG82_29255) 9719..9976 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T284397 WP_071177730.1 NZ_CP128194:c6004-5690 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT284397 WP_000093040.1 NZ_CP128194:c6270-5992 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References