Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 122928..123679 Replicon plasmid pVir_KP0714
Accession NZ_CP128192
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag QSG82_RS28005 Protein ID WP_014386536.1
Coordinates 123197..123679 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag QSG82_RS28000 Protein ID WP_004902250.1
Coordinates 122928..123206 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS27965 (QSG82_27965) 118571..118996 - 426 WP_000522996.1 organomercurial transporter MerC -
QSG82_RS27970 (QSG82_27970) 119024..119299 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
QSG82_RS27975 (QSG82_27975) 119315..119680 - 366 WP_001294656.1 mercuric ion transporter MerT -
QSG82_RS27980 (QSG82_27980) 119752..120207 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
QSG82_RS27985 (QSG82_27985) 120860..121318 + 459 WP_014386535.1 hypothetical protein -
QSG82_RS27990 (QSG82_27990) 122148..122489 + 342 WP_004902257.1 hypothetical protein -
QSG82_RS27995 (QSG82_27995) 122597..122809 + 213 WP_004902255.1 hypothetical protein -
QSG82_RS28000 (QSG82_28000) 122928..123206 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
QSG82_RS28005 (QSG82_28005) 123197..123679 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
QSG82_RS28010 (QSG82_28010) 124714..125253 + 540 WP_004902239.1 hypothetical protein -
QSG82_RS28015 (QSG82_28015) 125358..125750 + 393 WP_032442757.1 hypothetical protein -
QSG82_RS28020 (QSG82_28020) 125851..126606 + 756 WP_004902235.1 DUF2971 domain-containing protein -
QSG82_RS28025 (QSG82_28025) 126633..127280 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 rmpA / iutA / iucD / iucC / iucB / iucA 1..254123 254123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T284391 WP_014386536.1 NZ_CP128192:123197-123679 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT284391 WP_004902250.1 NZ_CP128192:122928-123206 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References