284387

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5038599..5040280 Replicon chromosome
Accession NZ_CP128191
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QSG82_RS25410 Protein ID WP_002885155.1
Coordinates 5038599..5039516 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag QSG82_RS25415 Protein ID WP_004151732.1
Coordinates 5039522..5040280 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS25390 (QSG82_25390) 5033905..5035425 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QSG82_RS25395 (QSG82_25395) 5035422..5036420 + 999 WP_002885172.1 ribose ABC transporter permease -
QSG82_RS25400 (QSG82_25400) 5036451..5037392 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QSG82_RS25405 (QSG82_25405) 5037467..5038474 + 1008 WP_004151731.1 carbohydrate kinase family protein -
QSG82_RS25410 (QSG82_25410) 5038599..5039516 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QSG82_RS25415 (QSG82_25415) 5039522..5040280 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QSG82_RS25420 (QSG82_25420) 5040366..5041094 - 729 WP_002885152.1 response regulator transcription factor -
QSG82_RS25425 (QSG82_25425) 5041367..5043514 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
QSG82_RS25430 (QSG82_25430) 5043744..5044430 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T284387 WP_002885155.1 NZ_CP128191:c5039516-5038599 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT284387 WP_004151732.1 NZ_CP128191:c5040280-5039522 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References