Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2377439..2379027 Replicon chromosome
Accession NZ_CP128191
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QSG82_RS11980 Protein ID WP_004199851.1
Coordinates 2377705..2379027 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QSG82_RS11975 Protein ID WP_002904790.1
Coordinates 2377439..2377705 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS11950 (QSG82_11950) 2372589..2373512 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
QSG82_RS11955 (QSG82_11955) 2373493..2374647 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QSG82_RS11960 (QSG82_11960) 2374993..2376372 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QSG82_RS11965 (QSG82_11965) 2376350..2376850 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QSG82_RS11970 (QSG82_11970) 2376847..2377173 + 327 WP_002904788.1 hydroxyisourate hydrolase -
QSG82_RS11975 (QSG82_11975) 2377439..2377705 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QSG82_RS11980 (QSG82_11980) 2377705..2379027 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QSG82_RS11985 (QSG82_11985) 2379044..2380336 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QSG82_RS11990 (QSG82_11990) 2380469..2381473 - 1005 WP_004199852.1 fimbrial protein -
QSG82_RS11995 (QSG82_11995) 2381461..2383962 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T284379 WP_004199851.1 NZ_CP128191:2377705-2379027 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT284379 WP_002904790.1 NZ_CP128191:2377439-2377705 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References