284374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 14645..15782 Replicon plasmid unnamed1
Accession NZ_CP128189
Organism Enterococcus faecium strain A2

Toxin (Protein)


Gene name zeta Uniprot ID Q54944
Locus tag QSU80_RS14050 Protein ID WP_001284311.1
Coordinates 14919..15782 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QSU80_RS14045 Protein ID WP_000301765.1
Coordinates 14645..14917 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSU80_RS14015 10253..11746 + 1494 WP_000947691.1 primase C-terminal domain-containing protein -
QSU80_RS14020 11881..12177 + 297 WP_000053907.1 replication control protein PrgN -
QSU80_RS14025 12201..13160 - 960 WP_002287225.1 IS30 family transposase -
QSU80_RS14030 13357..14037 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
QSU80_RS14035 14094..14321 + 228 Protein_17 chromosome partitioning protein ParA -
QSU80_RS14040 14413..14628 + 216 WP_001835296.1 peptide-binding protein -
QSU80_RS14045 14645..14917 + 273 WP_000301765.1 antitoxin Antitoxin
QSU80_RS14050 14919..15782 + 864 WP_001284311.1 zeta toxin family protein Toxin
QSU80_RS14055 16045..16782 - 738 WP_001038796.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QSU80_RS14060 16907..16990 - 84 WP_031929417.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
QSU80_RS14065 17039..17122 - 84 Protein_23 MLS leader peptide -
QSU80_RS14070 17508..18188 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
QSU80_RS14075 18245..18433 - 189 Protein_25 replication initiation protein -
QSU80_RS14080 19109..19195 + 87 WP_107532029.1 type I toxin-antitoxin system Fst family toxin -
QSU80_RS14085 19316..20005 - 690 WP_002321377.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / VanHAX - 1..31838 31838
- inside IScluster/Tn erm(B) - 841..18188 17347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32404.02 Da        Isoelectric Point: 6.9964

>T284374 WP_001284311.1 NZ_CP128189:14919-15782 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT284374 WP_000301765.1 NZ_CP128189:14645-14917 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1GVN
PDB 3Q8X

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References