Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 104566..106149 Replicon chromosome
Accession NZ_CP128182
Organism Stenotrophomonas maltophilia strain a7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QP025_RS00450 Protein ID WP_049459435.1
Coordinates 104566..105888 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QP025_RS00455 Protein ID WP_005407534.1
Coordinates 105892..106149 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP025_RS00435 99961..101595 - 1635 WP_005407530.1 TldD/PmbA family protein -
QP025_RS00440 101626..103257 - 1632 WP_012478715.1 TldD/PmbA family protein -
QP025_RS00445 103951..104565 + 615 WP_201862201.1 DUF938 domain-containing protein -
QP025_RS00450 104566..105888 - 1323 WP_049459435.1 type II toxin-antitoxin system HipA family toxin Toxin
QP025_RS00455 105892..106149 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
QP025_RS00460 106311..109997 - 3687 WP_024956262.1 indolepyruvate ferredoxin oxidoreductase family protein -
QP025_RS00465 110169..110804 + 636 WP_076738897.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49069.93 Da        Isoelectric Point: 6.6866

>T284368 WP_049459435.1 NZ_CP128182:c105888-104566 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGQWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGWGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT284368 WP_005407534.1 NZ_CP128182:c106149-105892 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References