Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 383400..384037 Replicon chromosome
Accession NZ_CP128168
Organism Halobacillus sp. ACCC02827

Toxin (Protein)


Gene name pemK Uniprot ID L5NDX6
Locus tag QRD89_RS02060 Protein ID WP_008632962.1
Coordinates 383687..384037 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A7Z2SU23
Locus tag QRD89_RS02055 Protein ID WP_026576976.1
Coordinates 383400..383681 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD89_RS02035 (QRD89_02035) 378967..379326 + 360 WP_026576978.1 holo-ACP synthase -
QRD89_RS02040 (QRD89_02040) 379395..380888 + 1494 WP_286096198.1 NAD(P)H-hydrate dehydratase -
QRD89_RS02045 (QRD89_02045) 380934..381956 + 1023 WP_008632968.1 outer membrane lipoprotein carrier protein LolA -
QRD89_RS02050 (QRD89_02050) 382101..383249 + 1149 WP_286096199.1 alanine racemase -
QRD89_RS02055 (QRD89_02055) 383400..383681 + 282 WP_026576976.1 hypothetical protein Antitoxin
QRD89_RS02060 (QRD89_02060) 383687..384037 + 351 WP_008632962.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QRD89_RS02065 (QRD89_02065) 384253..385122 + 870 WP_008632960.1 RsbT co-antagonist protein RsbRA -
QRD89_RS02070 (QRD89_02070) 385128..385484 + 357 WP_008632953.1 STAS domain-containing protein -
QRD89_RS02075 (QRD89_02075) 385487..385888 + 402 WP_008632951.1 anti-sigma regulatory factor -
QRD89_RS02080 (QRD89_02080) 385903..386913 + 1011 WP_026576975.1 PP2C family protein-serine/threonine phosphatase -
QRD89_RS02085 (QRD89_02085) 386979..387308 + 330 WP_008632949.1 STAS domain-containing protein -
QRD89_RS02090 (QRD89_02090) 387311..387787 + 477 WP_008632948.1 anti-sigma B factor RsbW -
QRD89_RS02095 (QRD89_02095) 387759..388538 + 780 WP_026576974.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12945.02 Da        Isoelectric Point: 7.0122

>T284366 WP_008632962.1 NZ_CP128168:383687-384037 [Halobacillus sp. ACCC02827]
VIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAEKYGFERNSVILLEQI
RTIDKQRLTDKITQLDEPMMQQVNKSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10837.34 Da        Isoelectric Point: 4.5577

>AT284366 WP_026576976.1 NZ_CP128168:383400-383681 [Halobacillus sp. ACCC02827]
MVLSDSMQEIVIRIPDNLLNEVDGFIQLENSDRSDFMCQATKMYLREKKQRHIRESMRRGYMEMAKINLNIASEAFQAEE
EADHTLEQLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2SU39

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z2SU23

References