Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2442027..2443005 Replicon chromosome
Accession NZ_CP128149
Organism Bacillus mycoides strain SIN3.2

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag QRE62_RS16175 Protein ID WP_002017051.1
Coordinates 2442027..2442767 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag QRE62_RS16180 Protein ID WP_000588712.1
Coordinates 2442880..2443005 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE62_RS16145 (QRE62_16135) 2437129..2437890 + 762 WP_286126733.1 ABC transporter ATP-binding protein -
QRE62_RS16150 (QRE62_16140) 2437996..2438706 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
QRE62_RS16155 (QRE62_16145) 2438825..2439238 + 414 WP_002012925.1 VOC family protein -
QRE62_RS16160 (QRE62_16150) 2439415..2440047 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
QRE62_RS16165 (QRE62_16155) 2440321..2440797 + 477 WP_113709452.1 MarR family winged helix-turn-helix transcriptional regulator -
QRE62_RS16170 (QRE62_16160) 2440951..2441688 + 738 WP_286126734.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QRE62_RS16175 (QRE62_16165) 2442027..2442767 + 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QRE62_RS16180 (QRE62_16170) 2442880..2443005 + 126 WP_000588712.1 hypothetical protein Antitoxin
QRE62_RS16185 (QRE62_16175) 2443081..2443257 + 177 WP_002127426.1 stage II sporulation protein SB -
QRE62_RS16190 (QRE62_16180) 2443434..2444903 + 1470 WP_002127427.1 aminoacyl-histidine dipeptidase -
QRE62_RS16195 (QRE62_16185) 2445263..2445412 + 150 WP_002069316.1 hypothetical protein -
QRE62_RS16200 (QRE62_16190) 2446126..2446785 + 660 WP_286126735.1 CatB-related O-acetyltransferase -
QRE62_RS16205 (QRE62_16195) 2447276..2447980 + 705 WP_002085517.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T284361 WP_002017051.1 NZ_CP128149:2442027-2442767 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT284361 WP_000588712.1 NZ_CP128149:2442880-2443005 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References