Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239229..239871 Replicon chromosome
Accession NZ_CP128149
Organism Bacillus mycoides strain SIN3.2

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRE62_RS05010 Protein ID WP_000635965.1
Coordinates 239521..239871 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QRE62_RS05005 Protein ID WP_000004570.1
Coordinates 239229..239516 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE62_RS04980 (QRE62_04970) 234393..235355 + 963 WP_002009966.1 UV DNA damage repair endonuclease UvsE -
QRE62_RS04985 (QRE62_04975) 235524..236072 - 549 WP_002139859.1 rhomboid family intramembrane serine protease -
QRE62_RS04990 (QRE62_04980) 236164..236523 + 360 WP_002009969.1 holo-ACP synthase -
QRE62_RS04995 (QRE62_04985) 236680..237630 + 951 WP_002124820.1 outer membrane lipoprotein carrier protein LolA -
QRE62_RS05000 (QRE62_04990) 237748..238917 + 1170 WP_282915247.1 alanine racemase -
QRE62_RS05005 (QRE62_04995) 239229..239516 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QRE62_RS05010 (QRE62_05000) 239521..239871 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRE62_RS05015 (QRE62_05005) 239940..242108 + 2169 WP_286126793.1 Tex family protein -
QRE62_RS05020 (QRE62_05010) 242166..242282 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QRE62_RS05025 (QRE62_05015) 242493..242948 + 456 WP_016095131.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284360 WP_000635965.1 NZ_CP128149:239521-239871 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT284360 WP_000004570.1 NZ_CP128149:239229-239516 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References