Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2421807..2422785 Replicon chromosome
Accession NZ_CP128137
Organism Bacillus mycoides strain SIN3.1

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag QRE64_RS12435 Protein ID WP_002032139.1
Coordinates 2421807..2422547 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag QRE64_RS12440 Protein ID WP_000588712.1
Coordinates 2422660..2422785 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE64_RS12405 (QRE64_12395) 2416860..2418212 + 1353 WP_113709454.1 DEAD/DEAH box helicase -
QRE64_RS12410 (QRE64_12400) 2418401..2418484 + 84 Protein_2361 SAM-dependent methyltransferase -
QRE64_RS12415 (QRE64_12405) 2418603..2419016 + 414 WP_002012925.1 VOC family protein -
QRE64_RS12420 (QRE64_12410) 2419194..2419826 - 633 WP_113709453.1 type 1 glutamine amidotransferase family protein -
QRE64_RS12425 (QRE64_12415) 2420101..2420577 + 477 WP_113709452.1 MarR family winged helix-turn-helix transcriptional regulator -
QRE64_RS12430 (QRE64_12420) 2420731..2421468 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QRE64_RS12435 (QRE64_12425) 2421807..2422547 + 741 WP_002032139.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QRE64_RS12440 (QRE64_12430) 2422660..2422785 + 126 WP_000588712.1 hypothetical protein Antitoxin
QRE64_RS12445 (QRE64_12435) 2422861..2423037 + 177 WP_002017052.1 stage II sporulation protein SB -
QRE64_RS12450 (QRE64_12440) 2423057..2423446 - 390 WP_002085522.1 YxeA family protein -
QRE64_RS12455 (QRE64_12445) 2423698..2425167 + 1470 WP_002127427.1 aminoacyl-histidine dipeptidase -
QRE64_RS12460 (QRE64_12450) 2425527..2425676 + 150 WP_002127428.1 hypothetical protein -
QRE64_RS12465 (QRE64_12455) 2426436..2427095 + 660 WP_002185858.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T284359 WP_002032139.1 NZ_CP128137:2421807-2422547 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT284359 WP_000588712.1 NZ_CP128137:2422660-2422785 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8N1U0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References