Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240786..241428 Replicon chromosome
Accession NZ_CP128137
Organism Bacillus mycoides strain SIN3.1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRE64_RS01350 Protein ID WP_000635965.1
Coordinates 241078..241428 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QRE64_RS01345 Protein ID WP_000004570.1
Coordinates 240786..241073 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE64_RS01320 (QRE64_01320) 235949..236911 + 963 WP_002009966.1 UV DNA damage repair endonuclease UvsE -
QRE64_RS01325 (QRE64_01325) 237081..237629 - 549 WP_002139859.1 rhomboid family intramembrane serine protease -
QRE64_RS01330 (QRE64_01330) 237721..238080 + 360 WP_002009969.1 holo-ACP synthase -
QRE64_RS01335 (QRE64_01335) 238237..239187 + 951 WP_002124820.1 outer membrane lipoprotein carrier protein LolA -
QRE64_RS01340 (QRE64_01340) 239305..240474 + 1170 WP_282915247.1 alanine racemase -
QRE64_RS01345 (QRE64_01345) 240786..241073 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QRE64_RS01350 (QRE64_01350) 241078..241428 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRE64_RS01355 (QRE64_01355) 241497..243665 + 2169 WP_113710264.1 Tex family protein -
QRE64_RS01360 (QRE64_01360) 243723..243839 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QRE64_RS01365 (QRE64_01365) 244050..244505 + 456 WP_016095131.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284358 WP_000635965.1 NZ_CP128137:241078-241428 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT284358 WP_000004570.1 NZ_CP128137:240786-241073 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References