Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2464936..2465914 Replicon chromosome
Accession NZ_CP128129
Organism Bacillus mycoides strain SIN2.2

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag QRE63_RS12770 Protein ID WP_002032139.1
Coordinates 2464936..2465676 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag QRE63_RS12775 Protein ID WP_000588712.1
Coordinates 2465789..2465914 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE63_RS12740 (QRE63_12775) 2459988..2461340 + 1353 WP_113709454.1 DEAD/DEAH box helicase -
QRE63_RS12745 (QRE63_12780) 2461530..2461613 + 84 Protein_2428 SAM-dependent methyltransferase -
QRE63_RS12750 (QRE63_12785) 2461732..2462145 + 414 WP_002012925.1 VOC family protein -
QRE63_RS12755 (QRE63_12790) 2462323..2462955 - 633 WP_113709453.1 type 1 glutamine amidotransferase family protein -
QRE63_RS12760 (QRE63_12795) 2463230..2463706 + 477 WP_113709452.1 MarR family winged helix-turn-helix transcriptional regulator -
QRE63_RS12765 (QRE63_12800) 2463860..2464597 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QRE63_RS12770 (QRE63_12805) 2464936..2465676 + 741 WP_002032139.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QRE63_RS12775 (QRE63_12810) 2465789..2465914 + 126 WP_000588712.1 hypothetical protein Antitoxin
QRE63_RS12780 (QRE63_12815) 2465990..2466166 + 177 WP_002017052.1 stage II sporulation protein SB -
QRE63_RS12785 (QRE63_12820) 2466186..2466575 - 390 WP_002085522.1 YxeA family protein -
QRE63_RS12790 (QRE63_12825) 2466827..2468296 + 1470 WP_002127427.1 aminoacyl-histidine dipeptidase -
QRE63_RS12795 (QRE63_12830) 2468656..2468805 + 150 WP_002127428.1 hypothetical protein -
QRE63_RS12800 (QRE63_12835) 2469565..2470224 + 660 WP_002185858.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T284357 WP_002032139.1 NZ_CP128129:2464936-2465676 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT284357 WP_000588712.1 NZ_CP128129:2465789-2465914 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8N1U0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References