Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239277..239919 Replicon chromosome
Accession NZ_CP128129
Organism Bacillus mycoides strain SIN2.2

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRE63_RS01345 Protein ID WP_000635965.1
Coordinates 239569..239919 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QRE63_RS01340 Protein ID WP_000004570.1
Coordinates 239277..239564 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRE63_RS01315 (QRE63_01315) 234440..235402 + 963 WP_002009966.1 UV DNA damage repair endonuclease UvsE -
QRE63_RS01320 (QRE63_01320) 235572..236120 - 549 WP_002139859.1 rhomboid family intramembrane serine protease -
QRE63_RS01325 (QRE63_01325) 236212..236571 + 360 WP_002009969.1 holo-ACP synthase -
QRE63_RS01330 (QRE63_01330) 236728..237678 + 951 WP_002124820.1 outer membrane lipoprotein carrier protein LolA -
QRE63_RS01335 (QRE63_01335) 237796..238965 + 1170 WP_113710263.1 alanine racemase -
QRE63_RS01340 (QRE63_01340) 239277..239564 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QRE63_RS01345 (QRE63_01345) 239569..239919 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRE63_RS01350 (QRE63_01350) 239988..242156 + 2169 WP_113710264.1 Tex family protein -
QRE63_RS01355 (QRE63_01355) 242214..242330 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QRE63_RS01360 (QRE63_01360) 242541..242996 + 456 WP_016095131.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284356 WP_000635965.1 NZ_CP128129:239569-239919 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT284356 WP_000004570.1 NZ_CP128129:239277-239564 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References