Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 271946..272585 Replicon chromosome
Accession NZ_CP128118
Organism Peribacillus frigoritolerans strain LN4

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QRD90_RS01450 Protein ID WP_034306610.1
Coordinates 272235..272585 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QRD90_RS01445 Protein ID WP_034306380.1
Coordinates 271946..272227 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD90_RS01425 (QRD90_01425) 268083..268673 - 591 WP_053537118.1 rhomboid family intramembrane serine protease -
QRD90_RS01430 (QRD90_01430) 268781..269131 + 351 WP_053537119.1 holo-ACP synthase -
QRD90_RS01435 (QRD90_01435) 269375..270379 + 1005 WP_053537120.1 outer membrane lipoprotein carrier protein LolA -
QRD90_RS01440 (QRD90_01440) 270598..271785 + 1188 WP_252297071.1 alanine racemase -
QRD90_RS01445 (QRD90_01445) 271946..272227 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
QRD90_RS01450 (QRD90_01450) 272235..272585 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QRD90_RS01455 (QRD90_01455) 272997..273824 + 828 WP_054398282.1 RsbT co-antagonist protein RsbRA -
QRD90_RS01460 (QRD90_01460) 273827..274183 + 357 WP_048682053.1 STAS domain-containing protein -
QRD90_RS01465 (QRD90_01465) 274187..274588 + 402 WP_053537122.1 anti-sigma regulatory factor -
QRD90_RS01470 (QRD90_01470) 274598..275608 + 1011 WP_252297072.1 PP2C family protein-serine/threonine phosphatase -
QRD90_RS01475 (QRD90_01475) 275668..276000 + 333 WP_034306369.1 anti-sigma factor antagonist -
QRD90_RS01480 (QRD90_01480) 275997..276470 + 474 WP_053537124.1 anti-sigma B factor RsbW -
QRD90_RS01485 (QRD90_01485) 276448..277236 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T284355 WP_034306610.1 NZ_CP128118:272235-272585 [Peribacillus frigoritolerans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT284355 WP_034306380.1 NZ_CP128118:271946-272227 [Peribacillus frigoritolerans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References