Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1394494..1395410 Replicon chromosome
Accession NZ_CP128116
Organism Bacillus halotolerans strain KF17

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag QRD86_RS07755 Protein ID WP_024121091.1
Coordinates 1394664..1395410 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag QRD86_RS07750 Protein ID WP_024121090.1
Coordinates 1394494..1394664 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD86_RS07715 (1391362) 1391362..1391688 + 327 WP_127695404.1 XkdW family protein -
QRD86_RS07720 (1391685) 1391685..1391849 + 165 WP_015715740.1 XkdX family protein -
QRD86_RS07725 (1391895) 1391895..1392734 + 840 WP_127695402.1 phage-like element PBSX protein XepA -
QRD86_RS07730 (1392787) 1392787..1393056 + 270 WP_106020445.1 hemolysin XhlA family protein -
QRD86_RS07735 (1393068) 1393068..1393331 + 264 WP_024121086.1 phage holin -
QRD86_RS07740 (1393344) 1393344..1394237 + 894 WP_127695400.1 N-acetylmuramoyl-L-alanine amidase -
QRD86_RS07745 (1394273) 1394273..1394410 - 138 WP_127695398.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QRD86_RS07750 (1394494) 1394494..1394664 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QRD86_RS07755 (1394664) 1394664..1395410 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QRD86_RS07760 (1395519) 1395519..1396520 - 1002 WP_024121092.1 inorganic phosphate transporter -
QRD86_RS07765 (1396533) 1396533..1397150 - 618 WP_010333926.1 DUF47 domain-containing protein -
QRD86_RS07770 (1397428) 1397428..1398744 - 1317 WP_099042852.1 serine/threonine exchanger -
QRD86_RS07775 (1399139) 1399139..1400089 + 951 WP_127695396.1 ring-cleaving dioxygenase -
QRD86_RS07780 (1400249) 1400249..1400329 + 81 Protein_1367 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T284354 WP_024121091.1 NZ_CP128116:c1395410-1394664 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT284354 WP_024121090.1 NZ_CP128116:c1394664-1394494 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References