Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 519039..519675 Replicon chromosome
Accession NZ_CP128116
Organism Bacillus halotolerans strain KF17

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QRD86_RS03160 Protein ID WP_003156187.1
Coordinates 519325..519675 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QRD86_RS03155 Protein ID WP_003225183.1
Coordinates 519039..519320 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD86_RS03135 (515394) 515394..515993 - 600 WP_024120294.1 rhomboid family intramembrane serine protease -
QRD86_RS03140 (516088) 516088..516453 + 366 WP_106020948.1 holo-ACP synthase -
QRD86_RS03145 (516619) 516619..517635 + 1017 WP_106021112.1 outer membrane lipoprotein carrier protein LolA -
QRD86_RS03150 (517752) 517752..518921 + 1170 WP_024120297.1 alanine racemase -
QRD86_RS03155 (519039) 519039..519320 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QRD86_RS03160 (519325) 519325..519675 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRD86_RS03165 (519791) 519791..520615 + 825 WP_081638235.1 RsbT co-antagonist protein RsbRA -
QRD86_RS03170 (520620) 520620..520985 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QRD86_RS03175 (520988) 520988..521389 + 402 WP_106020946.1 serine/threonine-protein kinase RsbT -
QRD86_RS03180 (521401) 521401..522408 + 1008 WP_024120300.1 phosphoserine phosphatase RsbU -
QRD86_RS03185 (522469) 522469..522798 + 330 WP_024120301.1 anti-sigma factor antagonist RsbV -
QRD86_RS03190 (522795) 522795..523277 + 483 WP_024120302.1 anti-sigma B factor RsbW -
QRD86_RS03195 (523243) 523243..524031 + 789 WP_024120303.1 RNA polymerase sigma factor SigB -
QRD86_RS03200 (524031) 524031..524630 + 600 WP_024120304.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T284353 WP_003156187.1 NZ_CP128116:519325-519675 [Bacillus halotolerans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT284353 WP_003225183.1 NZ_CP128116:519039-519320 [Bacillus halotolerans]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References