284351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 537395..538031 Replicon chromosome
Accession NZ_CP128114
Organism Bacillus safensis strain G6S3

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag QRD88_RS02620 Protein ID WP_024425388.1
Coordinates 537681..538031 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QRD88_RS02615 Protein ID WP_003214273.1
Coordinates 537395..537676 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD88_RS02595 (QRD88_02595) 533541..534146 - 606 WP_024425384.1 rhomboid family intramembrane serine protease -
QRD88_RS02600 (QRD88_02600) 534241..534606 + 366 WP_047202005.1 holo-ACP synthase -
QRD88_RS02605 (QRD88_02605) 534767..535783 + 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
QRD88_RS02610 (QRD88_02610) 535925..537100 + 1176 WP_212053075.1 alanine racemase -
QRD88_RS02615 (QRD88_02615) 537395..537676 + 282 WP_003214273.1 hypothetical protein Antitoxin
QRD88_RS02620 (QRD88_02620) 537681..538031 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRD88_RS02625 (QRD88_02625) 538148..538978 + 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
QRD88_RS02630 (QRD88_02630) 538983..539351 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QRD88_RS02635 (QRD88_02635) 539354..539755 + 402 WP_024425390.1 anti-sigma regulatory factor -
QRD88_RS02640 (QRD88_02640) 539766..540773 + 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
QRD88_RS02645 (QRD88_02645) 540833..541162 + 330 WP_024425392.1 anti-sigma factor antagonist -
QRD88_RS02650 (QRD88_02650) 541159..541647 + 489 WP_024425393.1 anti-sigma B factor RsbW -
QRD88_RS02655 (QRD88_02655) 541613..542401 + 789 WP_024425394.1 RNA polymerase sigma factor SigB -
QRD88_RS02660 (QRD88_02660) 542401..543000 + 600 WP_024425395.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T284351 WP_024425388.1 NZ_CP128114:537681-538031 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT284351 WP_003214273.1 NZ_CP128114:537395-537676 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References