Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /SpoIISA(toxin) |
Location | 2375399..2376377 | Replicon | chromosome |
Accession | NZ_CP128112 | ||
Organism | Bacillus mycoides strain G5S2 |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | J8I6P2 |
Locus tag | QRX95_RS12275 | Protein ID | WP_002017051.1 |
Coordinates | 2375399..2376139 (+) | Length | 247 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | R8HWP4 |
Locus tag | QRX95_RS12280 | Protein ID | WP_000588712.1 |
Coordinates | 2376252..2376377 (+) | Length | 42 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRX95_RS12245 (QRX95_12245) | 2370499..2371260 | + | 762 | WP_002165794.1 | ABC transporter ATP-binding protein | - |
QRX95_RS12250 (QRX95_12250) | 2371367..2372077 | + | 711 | WP_002165793.1 | class I SAM-dependent methyltransferase | - |
QRX95_RS12255 (QRX95_12255) | 2372196..2372609 | + | 414 | WP_002012925.1 | VOC family protein | - |
QRX95_RS12260 (QRX95_12260) | 2372786..2373418 | - | 633 | WP_002165792.1 | type 1 glutamine amidotransferase family protein | - |
QRX95_RS12265 (QRX95_12265) | 2373693..2374169 | + | 477 | WP_002017049.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
QRX95_RS12270 (QRX95_12270) | 2374323..2375060 | + | 738 | WP_002032137.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
QRX95_RS12275 (QRX95_12275) | 2375399..2376139 | + | 741 | WP_002017051.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
QRX95_RS12280 (QRX95_12280) | 2376252..2376377 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
QRX95_RS12285 (QRX95_12285) | 2376453..2376629 | + | 177 | WP_002017052.1 | stage II sporulation protein SB | - |
QRX95_RS12290 (QRX95_12290) | 2376649..2377017 | - | 369 | WP_033710085.1 | YxeA family protein | - |
QRX95_RS12295 (QRX95_12295) | 2377289..2378758 | + | 1470 | WP_002017054.1 | beta-Ala-His dipeptidase | - |
QRX95_RS12300 (QRX95_12300) | 2379410..2380594 | - | 1185 | WP_002165790.1 | collagen-like protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28512.20 Da Isoelectric Point: 8.3034
>T284350 WP_002017051.1 NZ_CP128112:2375399-2376139 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | J8I6P2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A366GQT1 |