Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2375399..2376377 Replicon chromosome
Accession NZ_CP128112
Organism Bacillus mycoides strain G5S2

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag QRX95_RS12275 Protein ID WP_002017051.1
Coordinates 2375399..2376139 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag QRX95_RS12280 Protein ID WP_000588712.1
Coordinates 2376252..2376377 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX95_RS12245 (QRX95_12245) 2370499..2371260 + 762 WP_002165794.1 ABC transporter ATP-binding protein -
QRX95_RS12250 (QRX95_12250) 2371367..2372077 + 711 WP_002165793.1 class I SAM-dependent methyltransferase -
QRX95_RS12255 (QRX95_12255) 2372196..2372609 + 414 WP_002012925.1 VOC family protein -
QRX95_RS12260 (QRX95_12260) 2372786..2373418 - 633 WP_002165792.1 type 1 glutamine amidotransferase family protein -
QRX95_RS12265 (QRX95_12265) 2373693..2374169 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
QRX95_RS12270 (QRX95_12270) 2374323..2375060 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
QRX95_RS12275 (QRX95_12275) 2375399..2376139 + 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QRX95_RS12280 (QRX95_12280) 2376252..2376377 + 126 WP_000588712.1 hypothetical protein Antitoxin
QRX95_RS12285 (QRX95_12285) 2376453..2376629 + 177 WP_002017052.1 stage II sporulation protein SB -
QRX95_RS12290 (QRX95_12290) 2376649..2377017 - 369 WP_033710085.1 YxeA family protein -
QRX95_RS12295 (QRX95_12295) 2377289..2378758 + 1470 WP_002017054.1 beta-Ala-His dipeptidase -
QRX95_RS12300 (QRX95_12300) 2379410..2380594 - 1185 WP_002165790.1 collagen-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T284350 WP_002017051.1 NZ_CP128112:2375399-2376139 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT284350 WP_000588712.1 NZ_CP128112:2376252-2376377 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References