Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 245596..246238 Replicon chromosome
Accession NZ_CP128112
Organism Bacillus mycoides strain G5S2

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRX95_RS01495 Protein ID WP_000635965.1
Coordinates 245888..246238 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QRX95_RS01490 Protein ID WP_000004570.1
Coordinates 245596..245883 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX95_RS01465 (QRX95_01465) 240911..241873 + 963 WP_002009966.1 UV DNA damage repair endonuclease UvsE -
QRX95_RS01470 (QRX95_01470) 241866..242438 - 573 WP_002167128.1 rhomboid family intramembrane serine protease -
QRX95_RS01475 (QRX95_01475) 242531..242890 + 360 WP_002009969.1 holo-ACP synthase -
QRX95_RS01480 (QRX95_01480) 243047..243997 + 951 WP_002091373.1 outer membrane lipoprotein carrier protein LolA -
QRX95_RS01485 (QRX95_01485) 244115..245284 + 1170 WP_002009971.1 alanine racemase -
QRX95_RS01490 (QRX95_01490) 245596..245883 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QRX95_RS01495 (QRX95_01495) 245888..246238 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRX95_RS01500 (QRX95_01500) 246307..248475 + 2169 WP_002029442.1 Tex family protein -
QRX95_RS01505 (QRX95_01505) 248534..248650 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QRX95_RS01510 (QRX95_01510) 248861..249316 + 456 WP_016095131.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284349 WP_000635965.1 NZ_CP128112:245888-246238 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT284349 WP_000004570.1 NZ_CP128112:245596-245883 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References