Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 618289..618925 Replicon chromosome
Accession NZ_CP128109
Organism Bacillus altitudinis strain D9_B_49

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QRD87_RS03160 Protein ID WP_003214169.1
Coordinates 618575..618925 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QRD87_RS03155 Protein ID WP_003214273.1
Coordinates 618289..618570 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD87_RS03135 (QRD87_03135) 614443..615048 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
QRD87_RS03140 (QRD87_03140) 615143..615508 + 366 WP_017358398.1 holo-ACP synthase -
QRD87_RS03145 (QRD87_03145) 615669..616685 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
QRD87_RS03150 (QRD87_03150) 616814..617995 + 1182 WP_035704220.1 alanine racemase -
QRD87_RS03155 (QRD87_03155) 618289..618570 + 282 WP_003214273.1 hypothetical protein Antitoxin
QRD87_RS03160 (QRD87_03160) 618575..618925 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRD87_RS03165 (QRD87_03165) 619040..619870 + 831 WP_058336383.1 RsbT co-antagonist protein RsbRA -
QRD87_RS03170 (QRD87_03170) 619875..620243 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QRD87_RS03175 (QRD87_03175) 620246..620647 + 402 WP_003214085.1 anti-sigma regulatory factor -
QRD87_RS03180 (QRD87_03180) 620658..621665 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
QRD87_RS03185 (QRD87_03185) 621725..622054 + 330 WP_008346902.1 anti-sigma factor antagonist -
QRD87_RS03190 (QRD87_03190) 622051..622539 + 489 WP_007496471.1 anti-sigma B factor RsbW -
QRD87_RS03195 (QRD87_03195) 622505..623293 + 789 WP_025206796.1 RNA polymerase sigma factor SigB -
QRD87_RS03200 (QRD87_03200) 623293..623892 + 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T284348 WP_003214169.1 NZ_CP128109:618575-618925 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT284348 WP_003214273.1 NZ_CP128109:618289-618570 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References