Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 247748..248390 Replicon chromosome
Accession NZ_CP128107
Organism Bacillus cereus strain D5_B_69

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRY07_RS02070 Protein ID WP_000635965.1
Coordinates 248040..248390 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QRY07_RS02065 Protein ID WP_000004570.1
Coordinates 247748..248035 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRY07_RS02040 (QRY07_02040) 242908..243870 + 963 WP_286119119.1 UV DNA damage repair endonuclease UvsE -
QRY07_RS02045 (QRY07_02045) 244041..244589 - 549 WP_002113424.1 rhomboid family intramembrane serine protease -
QRY07_RS02050 (QRY07_02050) 244682..245041 + 360 WP_002201995.1 holo-ACP synthase -
QRY07_RS02055 (QRY07_02055) 245198..246148 + 951 WP_002201994.1 outer membrane lipoprotein carrier protein LolA -
QRY07_RS02060 (QRY07_02060) 246266..247435 + 1170 WP_002201993.1 alanine racemase -
QRY07_RS02065 (QRY07_02065) 247748..248035 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QRY07_RS02070 (QRY07_02070) 248040..248390 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRY07_RS02075 (QRY07_02075) 248459..250627 + 2169 WP_002201992.1 Tex family protein -
QRY07_RS02080 (QRY07_02080) 250685..250801 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QRY07_RS02085 (QRY07_02085) 251009..251464 + 456 WP_002201991.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284346 WP_000635965.1 NZ_CP128107:248040-248390 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT284346 WP_000004570.1 NZ_CP128107:247748-248035 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References